PDF | Cissampelos pareira which is commonly known as velvetleaf belongs to the family Menispermaceae. Numbers of species are available all over the world . Cissampelos pareira f. emarginato-mucronata Chod. & Hassl. Synonym. Cissampelos pareira f. reniformis Chodat & Hassl. Synonym. Cissampelos pareira var. We show that an alcoholic extract prepared from Cissampelos pareira Linn inhibited the replication of dengue viruses in living cells in culture.

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Schematic representation of the antiviral screening assays. Effect of Cipa extract on RBCs.

Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals.

S4 Table Organ weights in Cipa extract-treated Wistar rats. In the control experiment, viral titers increased steadily reaching a plateau at day 3 post-infection. As before, mock-infections and DENV only infections in the absence of Cipa and paracetamol were also set up and parejra in parallel. Published online Dec AayurMed cultivates, sources, supplies and export Herbs for last 30 years across the globe.

The rest were effective at least against two other DENV serotypes.

Importantly, this extract did not show any toxic effects in rats and did not affect platelets and red blood cells. A converse experiment, again in type-1 format, was carried out to determine the inhibitory efficacy of the extract against DENV-3 stocks whose titers varied over 2 logs.

Cissampelos pareira in Flora of Pakistan @

These herbs are used for menstrual problems, hormonal imbalance, ease childbirth, postpartum pain, prevent threatened miscarriage, and control uterine hemorrhages, hormonal acne and cissapmelos syndrome. Traditional medicine-inspired approaches to drug discovery: Importantly, the reduction in viral titers was sustained over a period of several days. It is indigenous to the Amazon rain forest but also grows abundantly in India. Multiple physiological, haematological, biochemical and clinical parameters were monitored.

I agree to the terms and privacy policy. Treatments in Other Floras www. An excellent, if rather terse, guide to the traditional medicinal uses of the plants of the region.


Extracts were prepared using part s of the plants used in conventional Ayurvedic preparations.

All other authors have declared that no competing interests exist. At this juncture, two options in terms of future course of development could be envisaged.

Technology Biodiversity in India. In this context, it also becomes important to assess if Cissampeloss would have any effect on RBCs and platelets. The next experiment examined the effect of Cipa extract on the antipyretic activity of paracetamol using the Wistar rat pyrexia model.

Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals.

The results are shown in Fig 6A. A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. Natural History Natural History. Cissampelos mauritiana Thouars Cissampelos microcarpa DC. Aliquots of the culture supernatant were withdrawn at regular intervals over a period of several days and analysed for the presence of viral NS1 antigen and infectious virus, as shown in Fig 2.

Related observations Show all. It is to be ascertained in future if the protective efficacy may be further enhanced by extending the drug treatment regimen beyond 5 days.

At the end of the experiment, the survival data was used to plot Kaplan Meier survival curves and analysed by the log rank test Mantel-Cox test for statistical significance using GraphPad Prism 5 software.

After 24 hours of exposure to the extract, the monolayer was aspirated and overlaid with growth medium containing methyl cellulose and plaques developed 6 days later as above. The in vivo effect of Cipa extract in the presence and absence of paracetamol was assessed using the Wistar rat pyrexia model. An adenovirus type 5 AdV5 vector encoding an envelope domain III-based tetravalent antigen elicits immune responses against all four dengue viruses in the presence of pareirra AdV5 immunity.

European patent EP B1.

These data suggest that Cipa extract possesses anti-inflammatory activity in addition to the antipyretic activity documented in the experiment above. This may be of practical relevance to a dengue-endemic resource-poor country such as India.


Cissampelos Pareira

Possible outcomes in the type-2 assay are as follows: Considering that Cipa is in use for treating human ailments in Ayurvedic medicine in India [ 3233 ] and in traditional medicine in several countries in South America [ 34 ], pursuing the latter option could be a lot simpler and affordable, and of practical utility, particularly in the context of the resource-poor dengue-endemic countries.

Please enter your Email ID. This essentially corroborates an earlier report that the Cipa extract is essentially non-toxic and well tolerated in the animal model [ 29 ]. The plant has various therapeutic and medicinal uses.

This observation has led drug developers to hypothesize that lowering viremia by 1—2 logs may be associated with a favourable prognosis [ 14 ]. Ethnobotanical study of medicinal plants used by traditional users in Villupuram district of Tamil Nadu, India. False Pareira Root. Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: Ten years of dengue drug discovery: This is accompanied by potentially fatal manifestations of thrombocytopenia, haemorrhage, vascular leakage and shock [ 127 ].

In the absence of a licensed vaccine or antiviral drug, dengue continues to be a significant global public health problem [ 34 ]. The mice were monitored daily for mortality and the resultant data plotted as Kaplan-Meier survival curves.

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The type-1 assay was designed to identify herbal extracts that had the ability to block DENV from entering susceptible cells. Next, a complementary experiment was performed wherein DENV-3 was pre-incubated with increasing concentrations of Cipa extract for different periods of time before infection type-1 assay and overlay. Login eFloras Home Help. Best supported on Google Chrome, Firefox 3.