This review presents an analysis of the current data on the structural and functional organization and biological significance of epithelial cell rests of Malassez. Definition: The epithelial cell rests of Malasse are discrete clusters of residual cells from Hertwig’s epithelial root sheath (HERS) that didn’t. The authors performed a PubMed search on the term “epithelial rests” alone or in combination with “Malassez.” Relevant articles were categorized into primary.

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Experimental replantation of teeth in dogs and monkeys. Subsequently, ERM were considered as lymphatic channels coated by epithelium epithelual filled with lymph 8. The capacity to repair periodontium and to prevent cementum damages were connected with this process. Vascular changes in the periodontal ligament after removal of orthodontic forces.

[Epithelial cell rests of Malassez: tissue, cell, and molecular biology].

The concept of root resorptions or root resorptions are not multifactorial, complex, controversial or polemical! After the application of force, the change in the levels of periodontal capillary pressure can trigger blood supply dysfunction until its collapse, according to the force applied.

Orthodontic movement, however, does not promote ERM necrosis, but, rather, epirhelial the reverse. Epithelial rests colocalize with cementoblasts forming acellular cementum but not with cementoblasts forming cellular cementum.

Regulatory mechanisms of periodontal regeneration. His depth of knowledge on biophysics and laser treatments was simply outstanding.

Epithelial rests of Malassez: from latent cells to active participation in orthodontic movement

Tooth development Epithelial cells. Otherwise, more studies are necessary to clarify these functions and consequences in daily orthodontics practice. This would explain their role in maintaining a constant periodontal ligament space and would also explain their proliferation and implication in induced tooth movements.

Epithelial cell rests of Malassez have also been shown to malaszez when stimulated by induced tooth movements. A thorough understanding of the biological basis of maintenance of periodontal health is indispensable to many aspects of clinical dentistry in order that adequate dental treatment may be provided. During the early inflammatory events that compose the induced movement process, the constriction of the microvasculature of the periodontal ligament results in focal areas of necrosis, with histological features of hyalinization.


Epithelial rests’ function in replantation: The ERM cells indicated to present many functions at tooth movement after orthodontic forces. Thank you Scivision for a great opportunity. I highly appreciate the fact that SciVi-sion is so strongly focussed on education it’s dentists on the latest trending technology. Am J Orthod Resrs Orthop. C V Mosby; Retrieved from ” https: Our intention is to use lasers as an integrative dental tool so as to improve the overall outcome of general dentistry, paediatric dentistry, orthodontics, periodontistry and surgery.

Furthermore, experiments have established that epithelial cell rests of Malassez contain stem cells that can undergo epithelial-mesenchymal transitions, placing these cells at the centre of periodontal dpithelial. Role of the epithelial cell rests of Malassez in the development, maintenance and regeneration of periodontal ligament tissues. Epithelial cell rests of Malassez were first described by Augustin Serres in In infectious cases, lasers have a high disinfecting potential – enabling dentists to treat a wider variety of patients which they would not have been able to treat with conventional methods.

Malassez 7 was the first to detail the histological characteristics of epithelial rests and their distribution in the periodontal ligament.

Orthodontic o, in turn, is essentially a periodontal event that involves an acute inflammatory response during its initial phase. Oral histology and embryology. These molecules have proven potential for bone remodelling throughout life. Regeneration and repair of cement From the release of substances and differentiation of its epithelial cells, the remaining ERM play an important role in the formation and repair of cementum, particularly in the differentiation of cementoblasts with mesenchymal origin, preferably through the direct transformation of epithelial cells to cementoblasts.

Focal hyalinization during experimental tooth movement in beagle dogs.

Reviews on this topic are infrequent in the dental literature and the notable advances regarding the cytokine profile of the epithelial cell rests of Malassez and their autocrine and paracrine roles malassrz the periodontal tissues make it opportune to review their physiological roles in maintaining periodontal health. ERM incidence decreased with increasing age. The prevalence and distribution of rests of Malassez in the mouse molar and their possible role in repair and maintenance of the periodontal ligament.

The connective tissue that separates ERM from adjacent bone cells is believed to provide the essential dilution site for EGF, preventing this polypeptide from reaching the EGF receptors on bone cells in high concentrations thereby avoiding excessive bone resorption. The epithelial cell rests of Malassez: I’m optimistic that South Africa will soon be the strongest in the world in terms of using lasers in dentistry.


In dentistry, the epithelial cell rests of Malassez ERM or epithelial rests of Malassez pax epithelialis pediodontii are part of the periodontal ligament cells around reats tooth.

This result suggests the participation of ERM in the regeneration and repair of cementum. Alveolodental ankylosis is characterized by the absence of tooth elastin due to the loss of periodontal ligament cells associated with root resorption. ERM have been associated with the induction of this process from latent collagenase secretion in the extracellular matrix, allowing for the transformation of active collagenase enzymatic cleavage, resulting in the synthesis of collagen fibres.

epithelial cell rests of Malassez – – Human pathology

Services on Demand Article. Eur J Cell Biol. Periodontal tissue regeneration is a complex process that involves the collaboration of two hard tissues cementum and alveolar bone and two soft tissues gingiva and periodontal ligament. Initially, its latent or quiescent role was associated only to the formation of cysts and periapical granulomas. Dental papilla Epithelial root sheath Epithelial cell rests of Malassez Dental lamina Enamel organ Outer enamel epithelium Inner enamel epithelium Stellate reticulum Stratum intermedium.

The ERM are resulting from cell fragmentation of the Hertwig epithelial root sheath HERSan apical extent of internal and external epithelial enamel, which stimulates the differentiation of ectomesenchymal cells into odontoblasts, secreting root dentin. The results showed that the ERM were present in all 31 specimens analyzed regardless of agebut the incidence decreased with increasing age.

Find articles by Rafael Rodrigues Lima. Epithelial cell rests of Malassez contain unique stem cell populations capable of undergoing epithelial-mesenchymal transition. Expression of amelin and amelogenin in epithelial root sheath remnants of fully formed rat molars.